I am Gita Mishra, a research scholar at the department of Zoology, GGV. I am working under the supervision of Dr. Monika Bhadauria, associate professor at the Toxicology and pharmacology laboratory. I have been awarded with the Chhattisgarh young scientist award along with a cash prize of 21000 rupees and also an opportunity to work at any research institute to enhance my research.
My area of intret is to explore herbal remedies and to use them against drug induced side effects. Chhattisgarh is a home to a great variety of ethno medical plant species. Herbal medicines use different photochemical for the preventions and treatment of diseases which varies from traditional medicines of ancient times to present day standardized herbal drugs.
First line anti-tuberculosis drugs are used as an effective therapy against tuberculosis. Inspire of the availability of anti-tuberculosis drugs, around 1.4 million people died to tuberculosis in 2015. Major hurdle in tuberculosis eradication is noncompliance of the patients towards the drug. Due to the highly toxic effect of the drug, patients are unable to continue with the therapy for more than 6 months. Multi drug resistance hampers the random use of clinical medicines. The major challenge is to deal with the side effects of the drugs along with the disease itself. Herbal medicines are cheaper because of their easy availability. Herbal medicines are already accepted as an alternative. However clinical medicines use many plant derived metabolites in pharmaceutical drugs.
Drug included liver Injury (DILI) is a major health issue in India. India, Indonesia, china, Nigeria, Pakistan and South Africa accounted for 60% of the new cases. According to the Global tuberculosis report 2016, India accounts for more than a quarter of the world’s tuberculosis cases and deaths. Pathogenesis of ATD’s related hepatoxicity is not clearly known but oxidative stress is one of the mechanism which plays a central role in the pathogenesis of ATD induced hepatitis. Hemidesumus indices (Anantmool) is available in Chhattisgarh and India. My research work is an attempt to evaluate therapeutic potential of Hemidesmus indices against the first line anti –tuberculosis drug induced hepato-renal injury. The outcome if the study would be helpful in establishing plant based therapy and ATD included hepatic and renal diseases which would be beneficial for the patients to continue with their tuberculosis treatment.
Many many congratulations